Phenibut was developed in the Soviet Union in the 1960s, and has since been used to treat a wide range of ailments, including post-traumatic stress disorder (PTSD), anxiety, depression, asthenia, insomnia, alcoholism, stuttering, and vestibular disorders, among others. Phenibut is a phenylated GABA which allows it to cross the blood-brain barrier. Lack of GABA may result in bad mood. Most people don't even know that they have a GABA deficiency.
Sulbutiamine was first discovered in Japan in the 1930s, since then it has been used to treat asthenia. Asthenia is a condition of chronic fatigue that is cerebral rather than neuromuscular in origin. Sulbutiamine may improve memory, reduce psycho-behavioral inhibition, and improve erectile dysfunction.
L-Theanine is most commonly found in green, black, and white teas. It is also able to cross the blood-brain barrier. L-Theanine increases serotonin, dopamine, GABA, and glycine levels in various areas of the brain, as well as BDNF (Brain-Derived Neurotrophic Factor) and NGF (Nerve Growth Factor) levels in certain brain areas. L-Theanine has been studied for its potential ability to reduce mental and physical stress, improve cognition, and boost mood and cognitive performance.